Toxic relationship can have a devastating impact on a persons mental and emotional wellbeing. Here are some ways in which a toxic relationship can take a toll on you low self esteem when you’re in a toxic relationship you may constantly be criticized belittle or put down by your partner.Anxiety and depression toxic relationship can be stressful and emotionally draining. Which can lead to anxiety and depression. What isolation your partner may try to isolate you from friends and family. Or make you feel guilty for spending time with them.