This document, by GovTech, is a guide for health and human services (HHS) agencies on how to implement artificial intelligence (AI) to improve service delivery and client experiences. The guide explores five key areas where AI can have a significant impact: transforming the client experience, improving the employee experience, reducing administrative and regulatory burdens, promoting system efficiency and effectiveness, and predicting future patient and community health needs. The document also discusses challenges and considerations for implementing AI, including data privacy, algorithmic bias, and transparency, and includes success stories and best practices from various HHS agencies across the United States.