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How Depressive Disorder Affects Your Relationships Depressive disorder, or major depressive disorder (MDD), is a mental health condition that can have a profound impact on all areas of life, including relationships. While the person experiencing depression may be acutely aware of their internal struggles, their loved ones, including partners, friends, and family, may find it difficult to understand or cope with the changes in behavior and emotional responses. The effects of depression can be both emotional and physical, often creating distance, misunderstandings, and frustration within relationships. In this article, we will explore the various ways in which depressive disorder affects relationships and provide guidance for both individuals with depression and their loved ones on how to cope with these challenges.