Your body already makes GLP-1 every time you eat. The problem? Natural GLP-1 lasts about two minutes before an enzyme destroys it. Semaglutide and tirzepatide are engineered to do the same job, just louder and longer.

Dr. Clete Barrick breaks down how these medications work at three job sites: your pancreas, your stomach, and (most importantly) your brain. He explains the difference between homeostatic hunger and hedonic hunger, why GLP-1s quiet "food noise" through the brain's reward circuit, and why the "you only lose weight because you feel sick" myth is flat wrong.

In this episode:

• GLP-1: the hormone you already make
• Three job sites: pancreas, stomach, brain
• Homeostatic vs. hedonic hunger (the car wash sign analogy)
• Why less than 1% of weight loss comes from nausea
• Semaglutide vs. tirzepatide: what's different
• What GLP-1s don't do
• The Straight Shot: you are not cheating

No biochemistry degree required. Just the science you need to understand what's happening when you take your shot.

New episodes weekly. Subscribe and visit barrickhealth.com for physician-led weight loss care.