In this episode of Daily Value, we look at how paternal alcohol consumption before conception could influence offspring health, longevity, and even accelerate aging. Referencing studies from Andrology (PMID: 38044754) and Aging and Disease (PMID: 39122451), we examine how sperm RNA modifications and mitochondrial dysfunction may persist long after alcohol cessation—potentially programming offspring for metabolic disorders, reduced NAD+ levels, and faster cellular aging.

Discussion Points:

• Sperm Epigenetics: what rodent data tells us baout alcohol exposure altering small RNAs in sperm, disrupting gene regulation in the developing embryo.
• Mitochondrial Dysfunction: newer rodent data showing lower SIRT1/SIRT3 levels, and lower NAD+ in offspring whose parents were exposed to alcohol.
• Practical Takeaways: How long should alcohol cessation be before conception could help restore sperm quality and reduce the risk of accelerated aging in children for people who drink regularly.

https://pubmed.ncbi.nlm.nih.gov/39122451/ 

https://pubmed.ncbi.nlm.nih.gov/38044754/