Loperamide typically starts working within 1 hour to ease your diarrhea. Most people will have to take Loperamide only for 1 to 2 days but, you may need to take it for longer if you have diarrhea due to intestinal problems such as Crohn's disease, ulcerative colitis, or short bowel syndrome.

https://recoverypartnernetwork.com/drug/opioid/loperamide-abuse