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How to Lower Your ApoB | Is the Gut Microbiome Involved in Cholesterol Metabolism?
Welcome back to our podcast, in this episode we discuss how we are going to act upon our ApoB results that we shared previously. We aim to apply the current studies to our lifestyle and measure how effective our interventions have been in 3-4 months. There is a lot to discuss and we are aware that we cannot cover everything in this episode, also, please see our references below for any further reading.
If you would like to go to a particular section, please click on the time stamp below:
00:03 - Introduction
02:35 - How is the microbiome involved in cholesterol metabolism?
03:23- Coprostanol and its role in cholesterol homeostasis
04:27 - Cholesterol entrapment via gut bacteria
05:43 - Secondary bile acids produced by the gut microbiome
08:08 - The importance of a diverse gut microbiome
12:56 - How to increase your plant intake
14:14 - importance of probiotic for gut microbiome diversity
14:40 - prebiotics and the microbiome
15:09 - Can alcohol theoretically decrease the diversity of the gut microbiome?
16:14 - Is it easy for people with IBS to improve their gut microbiome?
18:18 - Fasting window and gut health
19:14 - antibiotic use and the impact on the gut microbiome
21:25 - does decreasing saturated fats in your diet have a direct effect on cholesterol/ APOB levels
24:18 - Impact of exercise on CVD risk, APOB and LDL-C
25:05 - how energy is used during different intensities of exercise - VO2max
31:03 - dietary carbohydrate consumption and its role in CVD risk
36:28 - Summary - what are we going to be doing going forward to improve our biomarkers?
41:05 - outro
Here are our podcast links:
https://open.spotify.com/show/5kJoyk0uY8u1H8CmgNDWzo?si=JF4_mY8oSES520KcOaHwhA
https://podcasts.apple.com/us/podcast/the-chemist-couple-podcast/id1773332678
Sign up to our newsletter and stay up to date with how we personally apply the science to enhance our lifestyle:
https://mailchi.mp/c15c44eee6a0/thechemistcouplepodcast
You can also watch this podcast episode on YouTube: https://www.youtube.com/channel/UCAf1zFQF4_dyVG4z8DD0_3Q
As always, this podcast is for informational purposes only and should not be used in substitute to seeing a healthcare professional. Any questions, please reach out to us and thanks for listening!
Here is a list of the sources that we used to make this podcast:
https://pmc.ncbi.nlm.nih.gov/articles/PMC4242964/#:~:text=Recently%2C%20regular%20exercise%20has%20been,apoA1%20ratio%20demonstrated%20significant%20interactions - exercise in overweight women on ApoB
https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1365-2796.2007.01806.x - exercise on ApoB- predominantly males
https://pmc.ncbi.nlm.nih.gov/articles/PMC5972657/#sec4 - saturated fats on ApoB
https://pmc.ncbi.nlm.nih.gov/articles/PMC7468809/#sec1-nutrients-12-02204 - Glycaemic index & load on lipid kinetics
https://www.ahajournals.org/doi/10.1161/ATVBAHA.120.315766#graphical-abstract - Saturated fats increasing atherogenicity of LDL-c
https://pmc.ncbi.nlm.nih.gov/articles/PMC7416843/ - gut microbiome & CVD
https://pmc.ncbi.nlm.nih.gov/articles/PMC7049528/ - high fibre diets on short chain fatty acids
https://pmc.ncbi.nlm.nih.gov/articles/PMC7230435/ - Gut microbiome & intestinal permeability
Guyton & Hall Medical Physiology 14th edition- general physiology overview
Rang & Dale’s Pharmacology 10th edition - general pharmacological overview
Links to cardiac screening - North West, UK
https://www.timcogleyfoundation.com
https://healthchecks.randoxhealth.com/tim-cogley-foundation
View all episodes
By The Chemist CoupleWelcome back to our podcast, in this episode we discuss how we are going to act upon our ApoB results that we shared previously. We aim to apply the current studies to our lifestyle and measure how effective our interventions have been in 3-4 months. There is a lot to discuss and we are aware that we cannot cover everything in this episode, also, please see our references below for any further reading.
If you would like to go to a particular section, please click on the time stamp below:
00:03 - Introduction
02:35 - How is the microbiome involved in cholesterol metabolism?
03:23- Coprostanol and its role in cholesterol homeostasis
04:27 - Cholesterol entrapment via gut bacteria
05:43 - Secondary bile acids produced by the gut microbiome
08:08 - The importance of a diverse gut microbiome
12:56 - How to increase your plant intake
14:14 - importance of probiotic for gut microbiome diversity
14:40 - prebiotics and the microbiome
15:09 - Can alcohol theoretically decrease the diversity of the gut microbiome?
16:14 - Is it easy for people with IBS to improve their gut microbiome?
18:18 - Fasting window and gut health
19:14 - antibiotic use and the impact on the gut microbiome
21:25 - does decreasing saturated fats in your diet have a direct effect on cholesterol/ APOB levels
24:18 - Impact of exercise on CVD risk, APOB and LDL-C
25:05 - how energy is used during different intensities of exercise - VO2max
31:03 - dietary carbohydrate consumption and its role in CVD risk
36:28 - Summary - what are we going to be doing going forward to improve our biomarkers?
41:05 - outro
Here are our podcast links:
https://open.spotify.com/show/5kJoyk0uY8u1H8CmgNDWzo?si=JF4_mY8oSES520KcOaHwhA
https://podcasts.apple.com/us/podcast/the-chemist-couple-podcast/id1773332678
Sign up to our newsletter and stay up to date with how we personally apply the science to enhance our lifestyle:
https://mailchi.mp/c15c44eee6a0/thechemistcouplepodcast
You can also watch this podcast episode on YouTube: https://www.youtube.com/channel/UCAf1zFQF4_dyVG4z8DD0_3Q
As always, this podcast is for informational purposes only and should not be used in substitute to seeing a healthcare professional. Any questions, please reach out to us and thanks for listening!
Here is a list of the sources that we used to make this podcast:
https://pmc.ncbi.nlm.nih.gov/articles/PMC4242964/#:~:text=Recently%2C%20regular%20exercise%20has%20been,apoA1%20ratio%20demonstrated%20significant%20interactions - exercise in overweight women on ApoB
https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1365-2796.2007.01806.x - exercise on ApoB- predominantly males
https://pmc.ncbi.nlm.nih.gov/articles/PMC5972657/#sec4 - saturated fats on ApoB
https://pmc.ncbi.nlm.nih.gov/articles/PMC7468809/#sec1-nutrients-12-02204 - Glycaemic index & load on lipid kinetics
https://www.ahajournals.org/doi/10.1161/ATVBAHA.120.315766#graphical-abstract - Saturated fats increasing atherogenicity of LDL-c
https://pmc.ncbi.nlm.nih.gov/articles/PMC7416843/ - gut microbiome & CVD
https://pmc.ncbi.nlm.nih.gov/articles/PMC7049528/ - high fibre diets on short chain fatty acids
https://pmc.ncbi.nlm.nih.gov/articles/PMC7230435/ - Gut microbiome & intestinal permeability
Guyton & Hall Medical Physiology 14th edition- general physiology overview
Rang & Dale’s Pharmacology 10th edition - general pharmacological overview
Links to cardiac screening - North West, UK
https://www.timcogleyfoundation.com
https://healthchecks.randoxhealth.com/tim-cogley-foundation