Howards Blend

Howards Blend

By Howard BlendEducationSelf-Improvement
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Howards Blend episodes

  • To Methylate Or Not To Methylate?

    Discuss my thoughts on whether Dimethylglycine or Trimethylglycine is "better" for Homocysteine conversion to Methionine.This is strictly for educational purposes. The information in this video is not meant as a substitute for professional medical advice.Please like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible.Resources: https://pmc.ncbi.nlm.nih.gov/articles/PMC4684116/https://cen.acs.org/articles/82/i3/METHYLMERCURY-TOXICOLOGY-PROBED.html#:~:text=%22Glutathione%20can%20be%20pumped%20out,brain%20as%20methylmercury%2Dglutathione.%22https://pmc.ncbi.nlm.nih.gov/articles/PMC4540061/https://www.sciencedirect.com/science/article/pii/S0163725821001182https://www.sciencedirect.com/science/article/pii/S0163725821001182 Image Resource:https://pmc.ncbi.nlm.nih.gov/articles/PMC6635095/ https://www.researchgate.net/figure/Overview-of-de-novo-glutathione-synthesis-Reduced-glutathione-or-GSH-is-a-tripeptide_fig2_5690064 https://lpi.oregonstate.edu/book/export/html/71 https://www.nature.com/articles/hr2011133 https://en.wikipedia.org/wiki/Serine_hydroxymethyltransferase - https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/methylenetetrahydrofolate-reductasehttps://chemtymology.co.uk/2020/11/27/cysteine-and-cystine/ https://fda.report/DailyMed/972f09a7-2aa1-4b1b-a6dc-2c4578a07803 https://www.thoughtco.com/definition-of-precipitate-604612 https://pubchem.ncbi.nlm.nih.gov/compound/Acetyl-p-benzoquinone-imine#section=3D-Conformer https://www.semanticscholar.org/paper/DRUG-METABOLISM-IN-THE-LIVER-Nguyen/4a29c6c4d433685a94b94602c012b8731cba5493https://pubchem.ncbi.nlm.nih.gov/compound/S-_Methylmercury_-L-Cysteine#section=2D-Structurehttps://keymerhealth.com/articles/seafood-mercury/https://onlinelibrary.wiley.com/doi/10.1155/2021/6564585 https://www.sciencedirect.com/science/article/abs/pii/S0304416519300133https://www.jbc.org/cms/10.1074/jbc.M111.265348/asset/822df563-eda2-4f48-a333-d01370a79e9c/main.assets/gr5_lrg.jpghttps://www.researchgate.net/figure/Betaine-metabolism-Metabolic-pathways-involving-betaine-BHMT-betaine-homocysteine_fig11_225081065https://www.acs.org/molecule-of-the-week/archive/c/l-cysteine.htmlhttps://biologydictionary.net/glutamic-acid/https://www.researchgate.net/figure/An-overview-of-the-reaction-catalyzed-by-SHMT-and-its-context-in-the-folate-cycle-A-The_fig1_338995871https://pubchem.ncbi.nlm.nih.gov/compound/5-Methyltetrahydrofolate#section=2D-Structurehttps://pubchem.ncbi.nlm.nih.gov/compound/Tetrahydrofolic-acid#section=2D-Structurehttps://pubchem.ncbi.nlm.nih.gov/compound/135398652#section=2D-Structure

    8 min
  • A Vital Antioxidant

    This episode goes over the compounds of N-acetylcysteine (NAC) and Glycine, and how they are used to make Glutathione. Also, we go over a couple of use cases for Glutathione. This is strictly for educational purposes. The information in this video is not meant as a substitute for professional medical advice.Please like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible.Resources: https://pmc.ncbi.nlm.nih.gov/articles/PMC4684116/https://cen.acs.org/articles/82/i3/METHYLMERCURY-TOXICOLOGY-PROBED.html#:~:text=%22Glutathione%20can%20be%20pumped%20out,brain%20as%20methylmercury%2Dglutathione.%22https://pmc.ncbi.nlm.nih.gov/articles/PMC4540061/https://www.sciencedirect.com/science/article/pii/S0163725821001182https://www.sciencedirect.com/science/article/pii/S0163725821001182 Image Resource:https://pmc.ncbi.nlm.nih.gov/articles/PMC6635095/ https://www.researchgate.net/figure/Overview-of-de-novo-glutathione-synthesis-Reduced-glutathione-or-GSH-is-a-tripeptide_fig2_5690064 https://lpi.oregonstate.edu/book/export/html/71 https://www.nature.com/articles/hr2011133 https://en.wikipedia.org/wiki/Serine_hydroxymethyltransferase - https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/methylenetetrahydrofolate-reductasehttps://chemtymology.co.uk/2020/11/27/cysteine-and-cystine/ https://fda.report/DailyMed/972f09a7-2aa1-4b1b-a6dc-2c4578a07803 https://www.thoughtco.com/definition-of-precipitate-604612 https://pubchem.ncbi.nlm.nih.gov/compound/Acetyl-p-benzoquinone-imine#section=3D-Conformer https://www.semanticscholar.org/paper/DRUG-METABOLISM-IN-THE-LIVER-Nguyen/4a29c6c4d433685a94b94602c012b8731cba5493https://pubchem.ncbi.nlm.nih.gov/compound/S-_Methylmercury_-L-Cysteine#section=2D-Structurehttps://keymerhealth.com/articles/seafood-mercury/https://onlinelibrary.wiley.com/doi/10.1155/2021/6564585 https://www.sciencedirect.com/science/article/abs/pii/S0304416519300133

    8 min
  • It’s Located Where?

    Discussing a question I received asking where the blood brain barrier is located. In addition, we go over information about the blood csf barrier. This is strictly for educational purposes. The information in this video is not meant as a substitute for professional medical advice.Here's a link to the previous video on the blood brain barrier.https://spotifycreators-web.app.link/e/BQceRCwlKRbPlease like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible.Resources:https://www.sciencedirect.com/topics/neuroscience/area-postrema#:~:text=The%20area%20postrema%20refers%20to,actions%20that%20lead%20to%20illness.https://qbi.uq.edu.au/brain/brain-anatomy/what-blood-brain-barrier#:~:text=The%20brain%20is%20precious%2C%20and,of%20the%20blood%E2%80%93brain%20barrier.https://www.cancer.gov/publications/dictionaries/cancer-terms/def/choroid-plexushttps://journals.lww.com/glaucomajournal/fulltext/2013/06001/production_and_circulation_of_cerebrospinal_fluid.5.aspxhttps://fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-020-00230-3https://my.clevelandclinic.org/health/articles/22266-meningeshttps://pmc.ncbi.nlm.nih.gov/articles/PMC2821375/https://www.frontiersin.org/journals/neuroanatomy/articles/10.3389/fnana.2021.665803/full#F1https://pmc.ncbi.nlm.nih.gov/articles/PMC1871727/https://pmc.ncbi.nlm.nih.gov/articles/PMC7768803/https://pmc.ncbi.nlm.nih.gov/articles/PMC4120694/Image resources:https://www.cancer.gov/publications/dictionaries/cancer-terms/def/choroid-plexushttps://med.libretexts.org/Bookshelves/Anatomy_and_Physiology/Anatomy_and_Physiology_%28Boundless%29/11%3A_Central_Nervous_System/11.3%3A_Protection_of_the_Brain/11.3C%3A_Ventricleshttps://www.hydroassoc.org/understanding-the-choroid-plexus-function-location-and-its-role-in-hydrocephalus/https://www.researchgate.net/figure/blood-cerebrospinal-fluid-CSF-barrier-The-choroid-plexus-has-fenestrated-capillaries_fig1_325373010https://neuroscientificallychallenged.com/glossary/fourth-ventriclehttps://www.researchgate.net/figure/Area-Postrema-is-Anatomical-Marker-for-the-Subregion-of-NTS-of-Primary-Hypothetical_fig1_259320952https://www.rit.edu/spotlights/blood-brain-barrierhttps://www.cell.com/heliyon/fulltext/S2405-8440%2824%2911593-9https://www.aginganddisease.org/EN/10.14336/AD.2022.0130-1http://epilepsygenetics.net/the-epilepsiome/slc2a1-this-is-what-you-need-to-know/https://www.mdpi.com/2072-6643/16/14/2363https://www.mdpi.com/2072-6643/11/11/2636https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2019.00282/fullhttps://teachmephysiology.com/immune-system/innate-immune-system/phagocytosis/https://oehha.ca.gov/chemicals/methylmercury-and-methylmercury-compoundshttps://www.mdpi.com/2073-4409/11/18/2823https://www.simplypsychology.org/brain-ventricles.htmlhttps://www.frontiersin.org/files/Articles/123479/fnins-09-00032-HTML/image_m/fnins-09-00032-g001.jpghttps://www.researchgate.net/figure/Cerebrospinal-fluid-flow-Cerebrospinal-fluid-is-mainly-produced-in-the-lateral_fig2_370857837https://www.physio-pedia.com/CSF_Cerebrospinal_Fluid

    18 min
  • BUM Energy Review

    Going 2 Deep (two active ingredients) in this review of BUM Energy Drink, root beer flavor.
    This is strictly for educational purposes. The information in this video is not meant as a substitute for professional medical advice.
    Please like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible.
    Image References:
    https://www.mdpi.com/1420-3049/27/12/3679
    https://courses.lumenlearning.com/wm-biology2/chapter/neural-stimulation-of-muscle-contraction/
    https://link.springer.com/referenceworkentry/10.1007/978-3-030-42634-7_52
    https://www.researchgate.net/figure/Tripartite-synapse-Participation-of-the-astrocyte-in-the-regulation-of-synapse-activity_fig3_366464810
    https://www.researchgate.net/profile/Francisco-Wandosell/publication/258282849/figure/fig1/AS:203001995239428@1425410855933/The-coordinated-action-of-glial-and-neuronal-purinergic-receptors-and-purines-in-the-CNS.png
    https://www.researchgate.net/figure/Schematic-drawing-of-ATP-and-adenosine-receptor-localization-on-different-cell-types-in_fig2_284132757
    https://www.mdpi.com/1422-0067/22/1/320
    https://brainstuff.org/blog/cellular-action-of-adenosine-receptors
    https://www.osmosis.org/notes/Motor_Nervous_System#page-16
    https://www.sciencefacts.net/resting-membrane-potential.html
    https://www.researchgate.net/figure/Sodium-Potassium-pump-which-uses-ATP-to-pump-sodium-ions-out-of-the-cell-The-hydrolysis_fig2_273751706
    https://jackwestin.com/resources/mcat-content/nerve-cell/nodes-of-ranvier-propagation-of-nerve-impulse-along-axon
    https://old-ib.bioninja.com.au/standard-level/topic-6-human-physiology/65-neurons-and-synapses/synaptic-transfer.html
    https://www.oist.jp/image/exocytosis-and-endocytosis-are-key-steps-vesicle-recycling-exocytosis-increases-surface-area
    https://www.sciencelearn.org.nz/images/2456-caffeine-and-adenosine-structure

    25 min
  • Crossing The BBB

    This episode goes over my two cents about a question I received. Does lecithin cross the blood brain barrier more effectively than choline?
    This is strictly for educational purposes. The information in this video is not meant as a substitute for professional medical advice.
    Please like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible.
    Information References:
    https://www.sciencedirect.com/science/article/abs/pii/S0197018615300802?via%3Dihub
    https://pmc.ncbi.nlm.nih.gov/articles/PMC1997116
    https://lpi.oregonstate.edu/mic/other-nutrients/choline
    https://pubmed.ncbi.nlm.nih.gov/14938439/
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6835836/
    https://ods.od.nih.gov/factsheets/Choline-HealthProfessional/
    Image References:
    https://cordancemedical.com/the-problem/blood-brain-barrier/
    https://www.researchgate.net/figure/Molecular-characteristics-of-tight-junction-TJ-protein-complexes-at-the-blood-brain_fig1_363511691
    https://www.sciencedirect.com/science/article/abs/pii/S1878818120304357
    https://www.ncbi.nlm.nih.gov/books/NBK114308/
    https://jissn.biomedcentral.com/articles/10.1186/1550-2783-4-5
    https://www.ncbi.nlm.nih.gov/books/NBK594255/
    https://pubchem.ncbi.nlm.nih.gov/compound/Choline
    https://pubchem.ncbi.nlm.nih.gov/compound/L-Tartaric-acid
    https://www.mdpi.com/2072-6651/8/11/326
    https://pmc.ncbi.nlm.nih.gov/articles/PMC8235064/
    https://www.examine.com/supplements/alpha-gpc/
    https://pmc.ncbi.nlm.nih.gov/articles/PMC10025538/
    https://pressbooks.calstate.edu/nutritionandfitness/chapter/6-2-phospholipids-and-sterols/
    https://lpi.oregonstate.edu/mic/other-nutrients/choline

    10 min
  • Lecithin VS Choline Part 2

    This is the second of a 2 part response to a question about lecithin vs choline.
    Here's the link to part 1.
    https://open.spotify.com/episode/2at2pXZQ02Wt9ZmYq3lczz?si=6exmen2-QjWM2fJ6aaItog
    Please like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible.
    Information References:
    https://www.sciencedirect.com/science/article/abs/pii/S0197018615300802?via%3Dihub
    https://pmc.ncbi.nlm.nih.gov/articles/PMC1997116
    https://lpi.oregonstate.edu/mic/other-nutrients/choline
    https://pubmed.ncbi.nlm.nih.gov/14938439/
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6835836/
    https://ods.od.nih.gov/factsheets/Choline-HealthProfessional/
    Image References:
    https://cordancemedical.com/the-problem/blood-brain-barrier/
    https://www.researchgate.net/figure/Molecular-characteristics-of-tight-junction-TJ-protein-complexes-at-the-blood-brain_fig1_363511691
    https://www.sciencedirect.com/science/article/abs/pii/S1878818120304357
    https://www.ncbi.nlm.nih.gov/books/NBK114308/
    https://jissn.biomedcentral.com/articles/10.1186/1550-2783-4-5
    https://www.ncbi.nlm.nih.gov/books/NBK594255/
    https://pubchem.ncbi.nlm.nih.gov/compound/Choline
    https://pubchem.ncbi.nlm.nih.gov/compound/L-Tartaric-acid
    https://www.mdpi.com/2072-6651/8/11/326
    https://pmc.ncbi.nlm.nih.gov/articles/PMC8235064/
    https://www.examine.com/supplements/alpha-gpc/
    https://pmc.ncbi.nlm.nih.gov/articles/PMC10025538/
    https://pressbooks.calstate.edu/nutritionandfitness/chapter/6-2-phospholipids-and-sterols/
    https://lpi.oregonstate.edu/mic/other-nutrients/choline
    https://www.researchgate.net/figure/molecular-structure-of-the-phosphatidylethanolamine-eluting-at-462-min_fig2_23771336
    https://www.nature.com/articles/srep16787
    https://www.researchgate.net/figure/Betaine-metabolism-Metabolic-pathways-involving-betaine-BHMT-betaine-homocysteine_fig11_225081065
    https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.1109445/full
    https://ncbi.nlm.nih.gov/books/NBK554408/
    https://www.researchgate.net/figure/A-simplified-illustration-of-the-homocysteine-metabolism-pathway-BHMT-betaine_fig1_341362341
    https://www.researchgate.net/figure/Fig-2-The-nucleus-basalis-of-Meynert-innervates-the-entire-cerebral-mantle-with_fig1_327756974
    https://www.researchgate.net/figure/The-human-cholinergic-system-Cholinergic-nuclei-are-primarily-located-in-numbered-cell_fig1_345346799

    10 min
  • Lecithin VS Choline Part 1

    This is the first of a two part response to a question about lecithin vs choline.

    Stay tuned for part 2.
    Please like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible.
    Information References:
    https://www.sciencedirect.com/science/article/abs/pii/S0197018615300802?via%3Dihub
    https://pmc.ncbi.nlm.nih.gov/articles/PMC1997116
    https://lpi.oregonstate.edu/mic/other-nutrients/choline
    https://pubmed.ncbi.nlm.nih.gov/14938439/
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6835836/
    https://ods.od.nih.gov/factsheets/Choline-HealthProfessional/
    Image Resources:
    https://cordancemedical.com/the-problem/blood-brain-barrier/
    https://www.researchgate.net/figure/Molecular-characteristics-of-tight-junction-TJ-protein-complexes-at-the-blood-brain_fig1_363511691
    https://www.sciencedirect.com/science/article/abs/pii/S1878818120304357
    https://www.ncbi.nlm.nih.gov/books/NBK114308/
    https://jissn.biomedcentral.com/articles/10.1186/1550-2783-4-5
    https://www.ncbi.nlm.nih.gov/books/NBK594255/
    https://pubchem.ncbi.nlm.nih.gov/compound/Choline
    https://pubchem.ncbi.nlm.nih.gov/compound/L-Tartaric-acid
    https://www.mdpi.com/2072-6651/8/11/326
    https://pmc.ncbi.nlm.nih.gov/articles/PMC8235064/
    https://www.examine.com/supplements/alpha-gpc/
    https://pmc.ncbi.nlm.nih.gov/articles/PMC10025538/
    https://pressbooks.calstate.edu/nutritionandfitness/chapter/6-2-phospholipids-and-sterols/
    https://lpi.oregonstate.edu/mic/other-nutrients/choline
    https://www.researchgate.net/figure/molecular-structure-of-the-phosphatidylethanolamine-eluting-at-462-min_fig2_23771336
    https://www.nature.com/articles/srep16787
    https://www.researchgate.net/figure/Betaine-metabolism-Metabolic-pathways-involving-betaine-BHMT-betaine-homocysteine_fig11_225081065
    https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.1109445/full
    https://ncbi.nlm.nih.gov/books/NBK554408/
    https://www.researchgate.net/figure/A-simplified-illustration-of-the-homocysteine-metabolism-pathway-BHMT-betaine_fig1_341362341
    https://www.researchgate.net/figure/Fig-2-The-nucleus-basalis-of-Meynert-innervates-the-entire-cerebral-mantle-with_fig1_327756974
    https://www.researchgate.net/figure/The-human-cholinergic-system-Cholinergic-nuclei-are-primarily-located-in-numbered-cell_fig1_345346799

    8 min
  • Increased Absorption?

    Replying to a question about how the absorption of choline be improved. This was a response on a choline bitartrate video, so I used that ingredient to explain.
    Please like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible.
    Image Resources:
    https://onlinelibrary.wiley.com/doi/10.1155/2021/6564585
    https://socratic.org/questions/how-is-the-structure-of-a-villi-in-the-small-intestine-related-to-its-function

    4 min
  • Antihistamines And Choline

    Answering a question regarding antihistamines and the effects on acetylcholine receptors.
    Please like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible.
    Resources:
    https://www.jacionline.org/article/S0091-6749(06)02977-0/fulltext
    https://www.ncbi.nlm.nih.gov/books/NBK557790/
    https://www.ncbi.nlm.nih.gov/books/NBK538188/
    https://pubmed.ncbi.nlm.nih.gov/11164999/
    https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14696
    https://www.ncbi.nlm.nih.gov/books/NBK526010/
    Image Resources:
    https://www.ebiohippo.com/en/aav-actone-gpcr-assay-kits.html
    https://www.science.org/doi/10.1126/science.aaw5188
    https://meducatmedical.com/what-is-continence/

    7 min
  • Citicoline Day Or Night?

    Discussing two questions I received.

    At what time should you take Citicoline? Also, does it work for the nervous system?
    Please like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible.

    7 min

About Howards Blend

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Each episode we explore topics that encourage free thought, promote wellness and taking responsibility for one's life.