In this episode, Aimee Altemus and Adelaide Frimpong speak with Dr. Gary Miller of Columbia University, a widely recognized leader in exposome research. Dr. Miller discusses how the exposome—the full spectrum of environmental exposures throughout a lifetime—is transforming our approach to human and environmental health. He highlights how exposomics, data science, and toxicology contribute to Next Generation Risk Assessment strategies to more accurately predict disease risk and guide public health strategies. From innovative technologies to ethical implications, this conversation offers a compelling look at the future of health science in a complex and rapidly changing world.