We are on the cusp of the fastest, deepest, most consequential transformation of human civilization in history, a transformation every bit as significant as the move from foraging to cities and agriculture 10,000 years ago. During the 2020s, key technologies will converge to completely disrupt the five foundational sectors that underpin the global economy, and with them every major industry in the world today. We discuss how the knock-on effects for society will be as profound as the extraordinary possibilities that emerge with James Arbib of Rethink X, an independent think tank that analyzes and forecasts the speed and scale of technology-driven disruption and its implications across society.