In this episode, we explore hyponatremia, a common yet complex electrolyte disorder in hospitalized adults. We discuss causes, diagnostic approaches, and treatment strategies, including the DDAVP clamp-bolus technique for precise sodium correction. We also review recent evidence showing that more rapid correction of severe hyponatremia may be associated with reduced mortality and shorter hospital stays without significantly increasing the risk of osmotic demyelination syndrome (ODS). Additionally, we highlight important cautions around the use of vaptans and emphasize the need for careful monitoring and individualized care in managing this challenging condition.