The PANCE Playbook

Hyponatremia Made Simple: Diagnose It, Correct It Safely | The PANCE Playbook


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Welcome back to The PANCE Playbook — your go-to podcast for clinically grounded, board-relevant medical education.

Hyponatremia is one of the most commonly tested electrolyte disorders on the PANCE — and one of the most dangerous to mismanage in real life. In this episode, we break down the systematic approach to diagnosing hyponatremia, walk through the key workup steps, and cover evidence-based correction strategies to help you avoid osmotic demyelination syndrome (ODS).

🧠 Topics covered:

  • Classifying hyponatremia (hypovolemic, euvolemic, hypervolemic)
  • Key labs: urine sodium, urine osmolality, serum osmolality
  • SIADH vs. other causes
  • Safe correction rates and the 10–12 mEq/L/day rule
  • When to use hypertonic saline, free water restriction, or fludrocortisone

🎯 Perfect for PA students, medical students, and anyone rotating through hospital medicine or internal medicine.

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The PANCE PlaybookBy The PANCE Playbook