The Chemical Collective discusses Ibogaine, a psychoactive and therapeutic substance derived from the Tabernanthe Iboga plant, primarily used in Central Africa for spiritual and healing purposes. Ibogaine's effects include reducing addiction cravings and withdrawal symptoms, potentially due to its interaction with serotonin, NMDA, dopamine, and opioid receptors. It's typically administered in a controlled clinical setting, often as Ibogaine hydrochloride, to ensure safety. Traditional Bwiti rituals involve consuming the root bark, which can lead to profound spiritual experiences. Despite its potential benefits, Ibogaine's use is associated with cardiovascular risks and requires careful monitoring.