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Implantation of paclitaxel-eluting stents in saphenous vein grafts: clinical and angiographic follow-up results from a multicentre study.
Objective: To define the clinical and angiographic follow-up results after implantation of paclitaxel-eluting
stents (PESs) in stenotic saphenous vein grafts (SVGs).
Design: Prospective multicentre study. Comparison with a control group.
Methods: 60 consecutive patients with 65 lesions located in 65 SVGs (mean (SD) age of vein grafts 11.3
(5.7) years) treated with PES (V-Flex Plus, 2.7 mg/mm2 paclitaxel, Cook) and 60 patients with 60 SVG
lesions treated with bare metal stent (BMS) were included. Lesions had to be ,20 mm in length and in grafts
of 2.75–3.5 mm diameter. The 6 month angiographic follow-up was obtained on 51 lesions (79%) of the PES
group and on 51 lesions (85%) of the BMS group.
Results: Baseline clinical and angiographic characteristics were comparable between both groups. At
angiographic follow-up, three vein grafts in the PES group and five vein grafts in the BMS group were
occluded. In-stent late lumen loss was lower in PES than in BMS (0.61 (0.81) vs 1.06 (0.72) mm, respectively;
p = 0.021). In-stent binary restenosis rates were 12% vs 33%, respectively, (p = 0.012). Linear regression
analysis showed BMS to be the only factor with an effect on late lumen loss (p = 0.011). Target-vessel failure
rates were 18% in the PES group and 41% in the BMS group (p = 0.019), whereas major adverse cardiac
event (MACE) rates at 180 days were 15% and 37%, respectively (p = 0.014).
Conclusions: Implantation of non-polymer-based PES in SVG lesions is associated with a lower late lumen
loss and restenosis rate than those of BMS. There remains a substantial target-vessel failure rate and MACE
rate even at 6 months owing to graft occlusion or new lesions in the graft.
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By Ludwig-Maximilians-Universität MünchenObjective: To define the clinical and angiographic follow-up results after implantation of paclitaxel-eluting
stents (PESs) in stenotic saphenous vein grafts (SVGs).
Design: Prospective multicentre study. Comparison with a control group.
Methods: 60 consecutive patients with 65 lesions located in 65 SVGs (mean (SD) age of vein grafts 11.3
(5.7) years) treated with PES (V-Flex Plus, 2.7 mg/mm2 paclitaxel, Cook) and 60 patients with 60 SVG
lesions treated with bare metal stent (BMS) were included. Lesions had to be ,20 mm in length and in grafts
of 2.75–3.5 mm diameter. The 6 month angiographic follow-up was obtained on 51 lesions (79%) of the PES
group and on 51 lesions (85%) of the BMS group.
Results: Baseline clinical and angiographic characteristics were comparable between both groups. At
angiographic follow-up, three vein grafts in the PES group and five vein grafts in the BMS group were
occluded. In-stent late lumen loss was lower in PES than in BMS (0.61 (0.81) vs 1.06 (0.72) mm, respectively;
p = 0.021). In-stent binary restenosis rates were 12% vs 33%, respectively, (p = 0.012). Linear regression
analysis showed BMS to be the only factor with an effect on late lumen loss (p = 0.011). Target-vessel failure
rates were 18% in the PES group and 41% in the BMS group (p = 0.019), whereas major adverse cardiac
event (MACE) rates at 180 days were 15% and 37%, respectively (p = 0.014).
Conclusions: Implantation of non-polymer-based PES in SVG lesions is associated with a lower late lumen
loss and restenosis rate than those of BMS. There remains a substantial target-vessel failure rate and MACE
rate even at 6 months owing to graft occlusion or new lesions in the graft.
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