Many patients with type 2 diabetes mellitus cannot be controlled with standard insulin agents due to obesity, insulin resistance, high risk of hypoglycemia, low adherence due to high injection burden, and the need for frequent glucose monitoring. Drs. Peters and Russell will review patient cases, and share practical information on concentrated insulins, including criteria for selection, switching strategies and dosing regimens, providing true practice-based learning particularly for clinicians in different geographic locations with high incidence rates of diabetes.