The 16th Century was quiet in Indiana after the Mississippian Indians left in 1500 A.D.. It wasn't until the mid 17th Century that new Indians began to drift into Indiana. French fur traders also appeared at that time. They used the Wabash River as vital  connection between French Canada and The Gulf of Mexico up the Mississippi and Ohio Rivers.

Fort Ponchartrain

Sieur Antoine de la Mothe Cadillac

Detroit River