This study investigated the connection between prior infections and long-term brain health. The study found that a history of infections like influenza and herpes viruses is associated with accelerated brain volume loss in specific regions and an increased risk of developing dementia. By analysing blood proteins, the researchers identified immunological drivers that may mediate this link between infection and neurodegeneration. Furthermore, genetic analysis suggested a potential causal role for certain infection-related proteins in brain atrophy, highlighting possible pathways for future interventions.

Research paper:

Duggan, M.R., Peng, Z., Sipilä, P.N. et al. Proteomics identifies potential immunological drivers of postinfection brain atrophy and cognitive decline. Nat Aging 4, 1263–1278 (2024).

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