This episode explores the ultimate "chameleons" of the GI tract, featuring bacterial, parasitic, and viral infections that mimic surgical emergencies. Learn how to avoid operating on a Campylobacter infection mimicking acute appendicitis or a Yersinia infection masquerading as Crohn's disease. The review highlights the shift to azithromycin over fluoroquinolones, the absolute contraindication of anti-motility agents in Shiga toxin-producing E. coli to prevent hemolytic uremic syndrome, and the high-stakes management of CMV and amoebic colitis in immunocompromised patients.