In this episode, we explore the groundbreaking FAME (Fractional Flow Reserve vs. Angiography for Multivessel Evaluation) trial, a pivotal study that reshaped how cardiologists approach multivessel coronary artery disease. Learn how measuring fractional flow reserve (FFR) changed the game in identifying which blockages truly need stenting — and which don't. We break down the study design, key findings, and lasting impact on clinical practice with expert insights.