The traditional healthcare system is breaking under the weight of burnout, short appointments, and profit-driven incentives, and Dr. Adam Wheeler has lived it from the inside. After losing a patient and realizing that all his creative energy was going into improving metrics instead of improving lives, he decided to build something radically different.

In this episode of Precision Medicine Made Simple, recorded live at Bigtree Medical in Columbia, Missouri, Dr. Wheeler joins host Taylor Cu and co-host Dr. William Stanford to share how he reimagined primary care from the ground up. His direct primary care network now serves more than 13,000 patients with a model built on unlimited time, transparent pricing, and authentic, patient-centered relationships.

You’ll hear how Dr. Wheeler’s model leverages nurse practitioners to expand access, integrates genetic and metabolic testing to personalize care, and embraces patient-requested treatments such as testosterone therapy, compounded GLP-1s, IV infusions, and preventive protocols. He also discusses how AI and shared decision-making empower patients to take control of their health, creating a system that rewards outcomes instead of volume.

This conversation explores what it truly takes to make healthcare personal again and why the future of medicine belongs to those willing to rebuild it from trust, data, and compassion.

Key Takeaways

• Why Dr. Wheeler walked away from the traditional insurance model
• How the direct primary care (DPC) membership system works and why patients love it
• The role of nurse practitioners in solving the physician shortage
• How Bigtree trains new NPs to lead with empathy and precision
• Why shared decision-making is critical to modern medicine
• What peptides, testosterone therapy, and GLP-1 medications mean for personalized care
• How AI tools are empowering, not replacing, doctors
• Why genetic and metabolic testing helps patients “know the fight they’re fighting”
• The real difference between health span and lifespan and how to extend both
• What the future looks like when healthcare becomes proactive instead of reactive

In This Episode

• [00:00] Turning points in medicine
• [01:17] Intro to Precision Medicine Made Simple
• [02:39] Meet Dr. Adam Wheeler
• [05:49] Membership model explained
• [07:23] Bigtree care models
• [08:19] Scaling intimacy in care
• [08:48] Direct vs. concierge care
• [09:51] Innovative patient care
• [31:34] Genetics and cancer risk
• [33:11] Personalized medicine
• [34:06] Motivational interviewing
• [35:11] Prostate cancer and genetics
• [49:50] AI in healthcare
• [53:01] AI’s role in medicine
• [56:39] Bigtree Medical vision
• [57:48] Final thoughts

Notable Quotes

• [05:43] “It’s really sad that all this creative energy is going to juicing the numbers, as opposed to taking care of people.” — Dr. Adam Wheeler 
• [05:24] “We allow our patients to leave our practice at any time. If we do a bad job, they’re supposed to leave, and if we do a good job, they stay.” — Dr. Adam Wheeler 
• [14:27] “The direct pay model absolutely changes your incentives as a doctor… it forces you to care about the things patients actually care about.” — Dr. Adam Wheeler
• [38:21] “There’s nothing you can do about the Lp(a), but you need to really optimize all of your other numbers.”— Dr. Adam Wheeler
• [55:19] "I think before we have AI replacing me, we're gonna have me enabled with AI." — Dr. Adam Wheeler

Our Guest

Dr. Adam Wheeler is a board-certified pediatrician and the founder of Bigtree Medical, a membership-based direct primary care practice based in Columbia, Missouri. Under his leadership, Bigtree serves over 13,000 patients and continues to expand access to affordable, compassionate, and high-quality healthcare. He has been recognized as Missouri’s Best Young Physician (2019) and Entrepreneur of the Year (2021) for his innovation in healthcare delivery.

Resources and Links

Dr. Adam Wheeler

• https://www.linkedin.com/in/adam-wheeler-a972a039/
• https://bigtreemedical.com/

Taylor Cu

• https://precision-medicine-made.captivate.fm/
• https://www.linkedin.com/in/taylorcu
• https://www.instagram.com/taylor_cu
• LinkedIn
• Instagram

Dr. William Stanford

• https://www.linkedin.com/in/william-stanford-md-phd-facp

Sponsored by: Biography Health

This episode is sponsored by Biography Health — where DNA-powered healthcare is designed just for you. Biography Health is a HIPAA-compliant precision medicine platform that equips providers with AI-driven recommendations powered by your genetics, health history, and clinical insights — all while keeping data private, secure, and independent from large EHR systems.

If you're a provider ready to bring precision medicine into your practice, visit BiographyHealth.com to learn more.

Or, if you're a patient who wants your doctor to explore this, point them our way — we’ll help them bring personalized healthcare to life.