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Generic Name

Aspart, Lispro, Glulisine

Trade Name

Novolog, Humalog, Apidra

Indication

hyperglycemia with diabetes type 1 and 2, diabetic ketoacidosis

Action

stimulates uptake of glucose into muscle and fat cells, inhibits production of glucose in the liver, prevents breakdown of fat and protein

Route Onset Peak Duration Aspart 10-20 min 1-3 hr 3-5 hr Glulisine 15 min 1 hr 2-4 hr Lispro 15 min 1-1.5 hr 3-4 hr Therapeutic Class

antidiabetics, hormones

Pharmacologic Class

pancreatics

Nursing Considerations

• assess for symptoms of hypoglycemia or hyperglycemia • monitor body weight over time • may cause decreased inorganic phosphates, potassium, and magnesium • monitor blood sugars every 6 hours, monitor A1C every 3-6 months