This episode explains how free radicals (ROS and RNS) drive tissue damage and delayed healing in diabetic foot ulcers, covering their sources, detection, and effects on cells, blood flow, nerves, and infection.

It also reviews the body’s antioxidant defenses and clinical strategies—glycemic control, debridement, advanced dressings, hyperbaric and topical oxygen, and antioxidant therapies—to reduce oxidative stress and promote healing.