Induced pluripotent stem cell (iPS cell) has been frequently applied in a serial of fields including diseasing modelling, drug screening, autologous cell therapy and biochemistry research. iPSCs can be obtained through the reprogramming of differentiated adult somatic tissue by ectopic expression of a set of core pluripotency-related transcription factors (OCT4, SOX2, KLF4, and MYC, OSKM). Nowadays, various virus delivery systems have been developed to deliver OSKM transcription factors into human or mouse fibroblasts.