Is Dysthymia Different from Depression? Key Differences Explained Dysthymia, now known as Persistent Depressive Disorder (PDD), and major depressive disorder (MDD) are both types of depression, but they are distinct in their duration, severity, and impact on a person’s life. While both conditions involve symptoms of sadness, hopelessness, and a lack of interest in activities, the key differences between dysthymia and major depression lie in their duration, intensity, and how they affect daily functioning. Understanding these differences is crucial for accurate diagnosis and appropriate treatment. In this article, we will explore the key differences between dysthymia and depression