Welcome to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, in today's episode, I will change the Queen's name of the fairytale of Pharmacology episode of today and it is Drug Dosage types. Today I will discuss this topic as it will form the building blocks to furnish the tail episodes of pharmacokinetics. Well, discussion starts from Fixed Dose in which I will state the fact that desired of drug can be attained well enough below the toxic dose. Second is variable dose with crude adjustments, in which I want to state that fine adjustments make insignificant differences and therapeutic endpoints are hard to monitor, and there may be variable situations, all explained well with apt examples. Third one is variable dose with fine adjustments, in this a vital function is closely monitored repeatedly and it provides endpoint, that is difference from last dose type. Fourth is maximum tolerated dose abbreviated as MTD, its used when ideal therapeutic effect is not achieved due to unwanted side effects, way of finding it is to monitor plasma concentration or to increase dose and follow another procedure, details discussed in podcast episode, last one is minimum tolerated dose, in this doses providing relief are too toxic to tolerate, compromise is to be done on safety grounds, it becomes a difficult unachievable task.That's all folks for today! Hope you all liked it, till next episode, do follow me here, do rate and review on ITunes, Apple podcasts, stay tuned, thank you!