Welcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay and in today's episode, we will trail through the nick of CYP isoenzymes, their connection and variability as far as interspecies and inter individual differences are concerned, few groups of drugs as examples are barbiturates, phenothiazines, imipramine, propranolol, etc. Then I will throw some light on few drugs metabolised by group of flavin mono oxygenases, then what you ought to know is how the latter differ from CYP isoenzymes, they cannot be induced or inhibited , they do not even show drug interactions. Next importantly we will have a word about non microsomal enzymes, which are found in cytoplasm, plasma, etc Their important examples are monoamine oxidases, esterases, amidases, transferases, conjugases, the main reactions they catalyse are phase 2 reactions except glucronide conjugation, and also catalyze reductions, hydrolytic reactions. These enzymes cannot be induced, but can be inhibited and show genetic variations also. That's all folks today, Its my son's birthday tomorrow, but me not in a hurry, I possess a sound mind, so do you all, so listening patiently to me, till next episode, do follow me here, stay tuned, do rate and review on ITunes , Apple Podcasts, thank you!!!