Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, in today's episode, I will be talking about a new type of receptor i.e. Ion Channels. Proteins act as ion selective channels, participate in trans membrane signalling, it makes them common targets of drug action. When operated directly by specific signal molecules, then we call them as Ligand gated, channels, they can be acted upon by G protein channels, there can also be voltage operated and stretch sensitive channels, there can be modulation of opening and closing of channels. All types are accompanied with great classic, important examples. As far as mechanism is concerned, the receptors are localised on cell membrane. Agonist regulated ion channels, they open due to depolarisation or hyperpolarisation of cell membrane. These ar known as Receptor operated channels(ROCs), these are different from Voltage operated channels (VOCs), then I will be listing the differences among the two. in ROC, channel and ligand binding site are separate, In VOC, there is "gating" controlled by changes in membrane potential.Then I will be defining in short-Agonist, Antagonist and Inverse agonist. Then explaining some structural details, I will be explaining the examples.with all such a lot of information, I will be calling it for a day, till next episode, do follow me here, do rate and review on ITunes, Apple podcasts, stay tuned, thank you!