Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, in today's episode, I will be talking about Some really important evidences to potentiate the fact that drugs act through receptors.First evidence to support he above stated sentence is that there is a great importance of structural specificity of action, to elaborate, specific chemical configuration is associated with a particular action, then I will give you examples of substitution at side chain , sometimes it may enhance the activity, sometime it may produce all in all a new compound and it may possess a new different action. Then a little word about chiral specificity of action of drugs.Apt examples beautify these statements.Secondly I will talk about Competitive antagonism between specific agonists and antagonists. Historical evidences by Langley and Ehrlich support this fact nicely. Thirdly, Clark propounded that cell possess special regions of reactivity. So all these facts show the importance of History, and how some amazing, wonderful discoveries have decorated the theory of the subject substantially.With all these new, crispy information bytes , i will wind up today's session, Wishing you all a great week ahead, do follow me here, stay tuned, do rate and review on ITunes, Apple podcasts, thank you!!