Welcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, in today's episode I will talk about Plateau principle of drug accumulation. In this field of discussion, firs of all I want to state that when a constant dose of drug is given repeatedly before expiry of 4 half lives, then this dose reaches a higher peak concentration, due to accumulation of fresh dose over already present dose. Now, with increase in concentration, increase in rate of elimination occurs, it finally balances the amount administered , leading to plasma concentration plateau of drug accumulation. This is definition of plateau principle of drug accumulation. Generally, steady state level. is achieved in 4 to 5 half lives unless the dose interval is longer than half life. The amplitude of fluctuations depends on dose interval i.e. difference between max and min levels is less if small doses are repeated frequently. Dose interval is actually a compromise between acceptable amplitude of fluctuations and convenient frequency of dosing. This and more new things are explained and a little diagram picture of plateau principle is explained as a graph between plasma concentration against time taken as in multiples of half lives. With this relaxing, convenient light note of weekend mood, wish you all a great , safe, sound weekend! Do follow me here, stay tuned, thank you!!