Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, in today's episode I will be adding value and new examples with information and definitions to the last episode, few concepts will definitely be revised and refreshed!!After all the breaks, festival omissions, in last topic's continuation, I will be telling that molecular forces alter configuration, its the dual receptor model, Ra and Ri, they might relate to open and closed state of ion channel, active and inactive receptor state, productive and non productive state respectively. When these configurations are in equilibrium, drug affinity determines the level of their perturbation, accordingly I will define and describe Agonist and Antagonist and these describe the main. two features affecting perturbation of equilibrium. Other subtypes to be defined and described are Partial agonist, example being Pentazocine at mu receptor of opioid receptor.The other subtype being Inverse agonist, the example being Beta carboline, inverse agonist at benzodiazepine receptor. Inverse agonists are also called Negative antagonists and are quite unique in their characteristics. Rest all details should be heard by lending your ears to the complete episode, with all these details and descriptions connected to the last episode, and advising to refer the beautiful diagrammatic depiction in last episode, I will just give a clue about my new Apple I Phone 11, do follow me here, do rate and review on ITunes, Apple podcasts, hope you all had a great weekend, thank you!!