In this episode, we look at a large, prominent trial that found no effect of prazosin on PTSD symptoms or sleep quality in veterans with a history of combat trauma. Why didn't this study find benefit from prazosin treatment, when many others had? And if so many other trials found benefit, why do this study anyway? . We get excited talking about inclusion criteria, and we say equipoise many, many times. The article we discuss is part of the ABPN MOC; none of the podcast authors are associated with the MOC, and we have no knowledge of the questions.