Found My Fitness - Rhonda Patrick

Podcast Notes Key Takeaways

• A 5 oz. glass of red wine contains ~1.8 milligrams of resveratrol
  • Therapeutic doses typically range from 100 milligrams to 1 gram
• Resveratrol exists in two molecular arrangements: trans- and cis-
  • Trans-resveratrol is the predominant form found in most supplements, and also the more stable (but if exposed to light, it can convert to the less-active cis-resveratrol)
  • Trans-resveratrol is more bioavailable if taken both in the morning and with food
• More data is needed to determine resveratrol’s effect on exercise
• Resveratrol activates a variety of anti-inflammatory and antioxidant response pathways
• Resveratrol is a calorie-restriction mimetic

Read the full notes @ podcastnotes.org

In this episode, Rhonda gives a summary of the science of resveratrol including its effects in animals and humans, mechanisms, and the bottom line on resveratrol supplementation and safety.

Learn more about resveratrol at our comprehensive overview

Relevant timepoints...

• 00:03:39 - Clinical effects of resveratrol in humans
• 00:04:10 - Effects on cardiovascular health biomarkers in humans
• 00:06:54 - Reduction of inflammatory biomarkers in humans
• 00:08:11 - Improved cognition and memory in clinical studies
• 00:11:23 - Healthspan improvements in animals
• 00:12:28 - Induction of longevity genes via xenohormesis
• 00:16:19 - Contradictory effects on exercise-associated benefits
• 00:20:34 - Various factors that affect resveratrol bioavailability
• 00:23:09 - Unintentional effects on drug metabolism

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