Is Schizotypal Personality Disorder Hereditary? Schizotypal Personality Disorder (STPD) is a mental health condition characterized by odd thoughts, eccentric behavior, and social anxiety. Many people wonder whether STPD has a genetic component and if it can be passed down through generations. While the precise cause of STPD remains unclear, there is significant evidence suggesting that genetics may play a role in its development. In this article, we will explore the hereditary aspects of Schizotypal Personality Disorder, examining the role of genetics and other environmental factors in the onset of the disorder.