What if the next big breakthrough in enamel repair isn’t a synthetic chemical at all, but peptides pulled straight from sheep’s wool?

Are we on the brink of a breakthrough in enamel repair or just spinning wool into wishful thinking? In this episode of Dental Formulator’s Playbook, Dr. Robert L. Karlinsey and co-host Tami unpack the latest research on wool-derived peptides, keratin, and elastin-like polypeptides as potential tools for enamel remineralization. From the origins of amelogenin to the science of polypeptide assembly and protein templating, they break down the complex biochemistry behind these buzzworthy innovations. But they don’t stop there, the hosts dive deep into formulation hurdles, clinical relevance, and the commercialization landmines that stand in the way of turning lab hype into reality.

🔍 Highlights ↠

• The science behind amelogenin and why it holds the key to enamel formation
• How keratin-derived peptides from sheep’s wool are being explored as a restorative enamel scaffold
• Why beta-sheet vs. alpha-helix structures matter for mineral templating
• The role of hydrophilic and hydrophobic domains in protein-calcium bonding
• Challenges with Curadont and why peptide-based pastes aren’t ready for toothpaste aisles
• Why aqueous vs. non-aqueous solvents can make or break peptide stability
• Deep dive into resin infiltration and how peptide delivery could disrupt this space
• Understanding T-E-G-D-M-A crosslinkers, keratin prep, and hydrogen bonding
• Overview of statherin-inspired peptides and their role in pellicle formation and mineral retention
• Commercialization barriers: patent positioning, formulation pitfalls, and the path from bench to brand

💡 Key Takeaways

• True enamel regrowth remains the holy grail—no current product fully delivers.
• Most protein-based innovations mimic nature, but stability, pH, and formulation compatibility are critical.
• Tooth remineralization isn't just about ingredients—it’s about the delivery system, the science, and the regulations.
• Protein-based oral care has promise, but formulating for real-world use is harder than it looks.

📲 Connect with Dr. Rob (Robert L. Karlinsey, PhD)

🌐 Website: customdentalformulations.com

 📄 Research Profile: Robert Karlinsey on ResearchGate