Isn't Life Curious?

Do we even test for the right things?

Now that medical and adult-use cannabis programs have been around for some time, and with them mandated lab testing of products – we have a lot of data that we can begin to review in order to assess how well we are managing the quality of cannabis in the market.

In this episode we are joined by microbiologist and analytical technologist Kyle Boyar to confront the idea that there may be some things that regulators require testing for that will almost never show up in a sample, while there are certain toxins that show up more often than we might expect which are NEVER required for testing in any state in the country.

What’s going on? Let’s dive in and find out!

Continuing our series on the issues facing the Cannabis testing industry, we sit down with Josh Swider of Infinite Chemical Analysis Labs to discuss the ways that he and his lab have felt the effects of potency inflation and lab shopping over the past several years. One by one Josh has watched clients disappear after complaints that his THC potency numbers were not high enough compared to his competitors. This is a story all too familiar to most labs that have ever operated in the space. Eventually the requests to boost THC results became much more direct as clients started offering bribes including outright briefcases full of cash. When he denied these advances, he began receiving death threats.

In an effort to understand just how bad the problem was, Josh and his team began collecting products off the shelf and testing them in the lab to see how the results compared to the original test results on record for the product. The results were alarming. Not only did he find evidence of potency fraud, but he also ended up finding evidence of various contaminants in products that somehow originally tested “clean.”

In this episode Josh and I take time to discuss his journey, how the industry has gotten into the situation it is in, and some potential solutions for moving the industry in a positive direction.

Learn more about iCAL: https://infinitecal.com/

In this extended 2+ hour episode, Josh Smith of Therapeutic Health Choice, an analytical lab based out of Michigan, takes us on a deep dive into his experiences of Cannabis testing fraud as we explore some potential ways to fix issues like lab shopping and bring scientific integrity back to the cannabis industry.

About Josh:

Josh Smith is a seasoned biotech executive with a graduate degree in Clinical Microbiology and over 24 years of experience in biotechnology, molecular biology, and pharmaceutical R&D. He has played a key role in pioneering various projects, including founding Premium CBD Labs and later Vardera Inc., where he built a nationally recognized laboratory network from the ground up. His work has led to several molecular biology patents, and he has served as an expert witness in legal cases across Wisconsin, Illinois, and Michigan.

Josh is actively involved in shaping industry standards through his participation in international method committees like AOAC and ASTM. He has also lobbied in Wisconsin, advocating for improved policies in the lab testing industry. In late 2023, he was part of the team that successfully overturned the compliance testing requirement for Aspergillus spp. in the state of Oregon.

Beyond his corporate roles, Josh is passionate about advancing scientific knowledge and innovation. He serves on the Curriculum Advisory Board for the graduate-level Cannabis Applied Science Program at Fanshawe College (London, ON), is a member of the Cannabis Science and Research Organization (Oregon), and is an editor for the Cannabis and Psychedelic Science Journal.

This is the first of a series of conversations with lab owners and industry experts revolving around the topic of fraud, mismanagement, and poor regulations facing Cannabis testing labs. With issues ranging from THC potency inflation, under-reporting of contaminants, perverse incentive structures promoted by regulations, market manipulation, and more – this series dives deep into a very controversial issue to try to understand the problem at its foundation and find meaningful and practical solutions forward to restore trust and bring greater transparency to the Cannabis industry.

Yasha Kahn is one of the co-founders of MCR Labs and spends much of his time diving into data. Over the past several years, Yasha has been on a mission to collect publicly available Cannabis testing data and make it accessible to the industry in hopes of promoting fruitful research, discussion, and regulatory changes to positively impact the industry. In this episode we dive into some of the data that Yasha has gathered and start to unpack the story that it tells.

Link to the raw data: https://drive.google.com/drive/folders/1IIlgudS3b1rvxbupeMaR_BdeUQmz3pOZ?usp=drive_link

There is no doubt that when it comes to aroma, the Cannabis plant is LOUD. Depending on the variety, a host of smells can be found in Cannabis ranging from the sweet and floral to the funky, gassy, savory, and beyond. Chemist Twinkle Paryani has been trying to understand the chemistry behind the spectrum of aromas found in Cannabis and recently unearthed some interesting findings.

Abstrax Tech: https://abstraxtech.com/

Twinkle’s publication “Nonterpenoid Chemical Diversity of Cannabis Phenotypes Predicts Differentiated Aroma Characteristics“: https://pubs.acs.org/doi/full/10.1021/acsomega.4c03225

In this episode of Isn’t Life Curious? we join comedian and social media sensation Rodney Norman to talk about the meaning of life and what exactly he finds so funny about it all. Throughout the conversation we are joined by some of Rodney’s friends including Leonard, the World’s Worst Motivational Speaker, to unpack some of their most profound insights about what it means to be alive.

Get ready to discover all the answers you have ever sought about life and the universe! It’s all packaged up for you in this single hour long conversation – available to you for free! (plus shipping and handling)

You can learn more about Rodney and find tour dates, merch and more at www.rodneynorman.com

“Have a super freakin’ awesome day!”

Stay curious, and take it easy!

Session Time Stamps

2:17 – Extraction Basics, Hydrocarbon Safety (2019)

1:35:18 – Remediation, CRC, Chromatography (2021)

3:17:16 – State of Industry in 2022, Medusa Stones, Gas Quality

5:40:33 – Lecture: Extraction Fundamentals (2021)

7:38:06 – Lecture: “Liquid Diamonds” and Product Terminology (2024)

Turn a long drive or your lab’s downtime into a masterclass in extraction and lab safety with extraction technologist and natural products formulator Murphy Murry in this special 9-hour mega-compilation!

CAC Sessions present compilations of conversations with guests through the years of the CAC podcast. The Murphy Murri Sessions presents 9 hours of conversations and lectures featuring extraction technologist and natural products formulator Murphy Murri. This mega-compilation starts with Murphy’s first appearance on the podcast in 2019 where we discuss extraction basics, hydrocarbon safety, and lab quality. This is followed by several additional podcast appearances where we dive into extract remediation, medusa stones, CRC, chromatography, and more. The Sessions are then capped with two previously unreleased lectures focusing on extraction fundamentals and product terminology.

​To kick off the new show, I wanted to re-release my conversation with Dr. Steven Novella, most famously known as the producer and host of The Skeptic’s Guide to the Universe Podcast and author of The Skeptic’s Guide to the Universe book. Dr. Novella is a neurologist and professor at Yale School of Medicine and an advocate of the skepticism movement. In our conversation we talk about the concept of reality vs perception and how to evaluate whether we are in touch with reality or are lost in our own fictions and hallucinations that our brains produce for us so easily. We discuss some of the cognitive biases that we wrestle with every day, common misconceptions about skepticism, the failings of public education in promoting critical thinking skills in kids, the severe consequences that may be in store if humans can’t learn to think better, and much more!

Learn more about The Skeptic’s Guide to the Universe at https://www.theskepticsguide.org/

Stay curious!

The Curious About Cannabis Podcast is now a show on the Isn’t Life Curious? network. Isn’t Life Curious? continues the curious quest of biologist and science educator Jason Wilson, MS as he delves into the complexities and wonders of life on Earth through engaging conversations with a diverse range of guests, including critical thinkers, philosophers, comedians, and everyday people. Each episode offers listeners a chance to explore profound questions about our human experience, making it a perfect listen for those who love to ponder the curious nature of life.

How does CBD affect the CB1 receptor, really?

Rob Laprairie is a cannabinoid researcher out of the University of Saskatchewan who was involved in the discovery of CBD’s allosteric binding activity on the CB1 receptor – leading to a host of speculative theories about how CBD influences the activity of THC. In this conversation, continuing our Train with Mary Jane series, we sit down with Rob and discuss his work studying the CB1 receptor to better understand how CBD and “minor” cannabinoids from Cannabis affect the body. Rob helps break down common misunderstandings about CBD’s effects, explains how our understanding of chemical receptors is evolving, and what the future of cannabinoid research may look like.

“Allosteric and orthosteric pharmacology of cannabidiol and cannabidiol-dimethylheptyl at the type 1 and type 2 cannabinoid receptors”: https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14440