In this issue, learn about terminal sterilization of pharmaceutical products.

Click here to download a PDF, readable version of Issue 21: https://www.altasciences.com/sites/default/files/2021-12/The-Altascientist_issue-21_Terminal-Sterilization.pdf

There is growing demand for sterilization of small-molecule parenteral products, including heart medications, eye drops, analgesics, and antibiotics, as well as common intravenous solutions such as glucose, potassium, and saline. Many such products are used by medical professionals in hospitals, and to ensure patient safety, the drug products and related instruments and materials are sterilized at manufacture. This ensures there are no microbial contaminants like fungi or bacteria present when the product is used.

CHAPTERS:

- 0:00 — Section 1: Introduction

- 1:12 — Section 2: Terminal vs. Aseptic Sterilization of Pharmaceutical Products

- 5:41 — Section 3: Terminal Sterilization Methods for Pharmaceuticals

- 9:03 — Section 4: Validation Steps

- 13:11 — Section 5: Material Changes

- 14:12 — Section 6: Method Selection

- 15:01 — Section 7: Why Terminal Sterilization

- 16:31 — Conclusion

About Altasciences:

Altasciences is an integrated drug development solution company offering pharmaceutical and biotechnology companies a proven, flexible approach to preclinical and clinical pharmacology studies, including formulation, manufacturing, and analytical services. For over 25 years, Altasciences has been partnering with sponsors to help support educated, faster, and more complete early drug development decisions. Altasciences’ integrated, full-service solutions include preclinical safety testing, clinical pharmacology and proof of concept, bioanalysis, program management, medical writing, biostatistics, clinical monitoring, and data management, all customizable to specific sponsor requirements. Altasciences helps sponsors get better drugs to the people who need them, faster.