Maximizing bioavailability is a critical aspect of drug development, ensuring that the maximum therapeutic effect is achieved with the minimum dose. By rigorously evaluating and optimizing the chemical, physical, and biological properties of the API, pharmaceutical scientists can enhance bioavailability, leading to more effective and reliable medications.

In this issue, we review different analytical testing techniques that support drug product development specific to bioavailability.

Contents include:

- API characterization

- Common techniques for determining particle size distribution

- Formulation approaches to maximize bioavailability

- Case study: manufacturing of a nanosuspension