Accompanying the January 2022 issue of JACI: In Practice is a supplement providing unique and comprehensive guidance regarding the management of asthma. Listen as JACI: In Practice Editor-in-Chief, Michael Schatz, describes the contents, including the Executive Summary of the 2021 Global Initiative for Asthma (GINA) Strategy Report, a comparison of the 2020 National Asthma Education and Prevention Program (NAEPP) Guideline Update to the GINA report, and a practical guide to implementation of single inhaler maintenance and reliever therapy (SMART), which is recommended in both guidance documents but present a new paradigm for many practicing clinicians. Read the Supplement: https://bit.ly/JAIPJan2022Supp. Access JACI: In Practice’s entire library: https://www.jaci-inpractice.org