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In a groundbreaking study published in Stroke, researchers tackle the "Large-Core Paradox," challenging the long-held belief that large-core strokes preclude good outcomes post-reperfusion. They found endovascular treatment (EVT) significantly improves functional outcomes, even in large-core patients, questioning the core/penumbra model's reliability. This study is a game-changer, highlighting the need for more accurate imaging to assess core extent and the potential for salvage in large-core strokes. Tune in for more on this paradigm-shifting research!