Hey there, it's time to dive into the latest medical breakthroughs with Research Mews! Download the AI-powered research assistant app, SciMiao, at labcat.com.cn to boost your research efficiency. Today, we're spotlighting a groundbreaking review in "Briefings in Bioinformatics" that bridges artificial intelligence and biological sciences. Large language models (LLMs) are revolutionizing bioinformatics, showing significant progress in analyzing complex biological data. This comprehensive review explores LLMs' advancements in protein and nucleic acid structure prediction, omics analysis, drug design, and biomedical literature mining. It also addresses the challenges of model interpretability and data bias. Tune in to learn how LLMs are becoming essential tools in bioinformatics research and driving innovations in biomedical fields.