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In today's top article from the Journal of Hepatology, researcher Chan SL and team are shaking up hepatobiliary cancer treatment. They're targeting new immune checkpoints and developing novel therapies beyond the usual suspects like PD-1 and CTLA-4. Exciting stuff, right? We're talking phase II and III clinical trials, cellular therapies, and even bispecific antibodies. Plus, they're tackling tough targets like PPAR-alpha and β-catenin with new drugs and antibody-drug conjugates. These advances could revolutionize treatment for rare liver cancer subtypes. Isn't it thrilling to see science making strides in the fight against cancer? Tune in for a deeper dive into this groundbreaking research.