JACI: In Practice Associate Editor, David Khan, describes the June 2021 issue, the theme of which is “Urticaria and Angioedema.” Theme topics covered include pathogenesis, genetic aspects, measurement of disease activity and control, triggers of exacerbations, hormonal effects, and newer treatments. Dr. Khan then presents the Highlights of the Original Articles in the issue, which are on the topics of COVID-19, Urticaria and Angioedema, Allergic Bronchopulmonary Aspergillosis, Anaphylaxis, Asthma, Drug Allergy, Eosinophilic Disorders, Food Allergy, and Rhinitis and Sinusitis. Read the issue: https://bit.ly/JAIPJune2021. Access JACI: In Practice’s entire library: https://www.jaci-inpractice.org