The city of Antioch is one of the most important in the history of Christianity. God was raising up Paul as he worked in that church, and it would become a center of operations for the Church for years to come. It’s no coincidence that the Spirit went ahead of them, and that God was creating this new base of operations. Most of the believers in that day would have probably looked to Jerusalem, that’s certainly where the apostles were spending a lot of time. But God isn’t interested in doing things we expect. Sometimes our greatest growth comes from the times when he surprises us, does something somewhere else, and challenges us to meet him where he’s taking us.