Surface chemistry on gold nanoparticles is one of the quiet levers that decides how your lateral flow test performs in the real world. In this episode of Expert Insights, host Mitzi Rettinger and DCN Dx COO Patrick Vaughan, Ph.D., talk with Kimialys’ Claude Noguès, Ph.D. (CSO) and Cyril Gilbert (CEO) about K-One, their patented approach to controlling ligand orientation and minimizing non-specific interactions on gold. We translate the chemistry into practical decisions for assay developers and product managers.

Presented in partnership with Kimialys, Gold Sponsor of ALFC 2025. Podcast listeners can enjoy 25% ALFC in-person and virtual registrations by using code ALFC25 at checkout.

Guests

Claude Noguès, Ph.D., CSO, Kimialys

Cyril Gilbert, CEO, Kimialys

Host

Mitzi Rettinger, CRO, DCN Dx

Pat Vaughan, Ph.D. COO, DCN Dx

What you’ll learn

• How ligand orientation and usable surface area on gold influence LoD, reproducibility, and matrix tolerance

• Where K-One coated gold bioconjugates can help, and the caveats to keep in mind when translating results

• Buying criteria that actually matter

• Scale-up watchouts

Who should listen

LFA and rapid test developers, R&D and product managers, operations leaders, and quality and verification leads.