Pharmacy - Emergency Medicine Deep Dive Podcast

Ketamine and Second-Line Agents in Status Epilepticus Management


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Status epilepticus is a true neurologic emergency where every minute matters. In this episode, we review modern emergency management strategies, starting with benzodiazepines as first line therapy and examining why traditional second line agents like levetiracetam often fall short in rapidly stopping seizures. We explore growing evidence supporting the early use of ketamine, highlighting its ability to terminate refractory seizures while maintaining hemodynamic stability and often avoiding immediate intubation. The discussion emphasizes the importance of adequate early dosing and decisive escalation to prevent long term neurologic injury. Ultimately, this episode makes the case for faster, more aggressive intervention to achieve seizure control within the critical first thirty minutes.

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Pharmacy - Emergency Medicine Deep Dive PodcastBy Anthony Lau