In this episode, we explore the potential of ketamine as a neuroprotective therapy for patients recovering from cardiac arrest. Brain injury after arrest often follows a “two-hit” process of ischemia and reperfusion, triggering toxic chemical cascades that damage neurons. As an NMDA receptor antagonist, ketamine may interrupt these pathways and help preserve cognitive function. While animal studies show promise, human clinical trials in this population are still lacking. We also discuss how modern evidence challenges old concerns about ketamine and intracranial pressure, highlighting the need for future research on its role in post-arrest neurological outcomes.