PaperPlayer biorxiv physiology

KHz-rate volumetric voltage imaging of the whole zebrafish heart


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Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2020.07.13.196063v1?rss=1
Authors: Sacconi, L., Silvestri, L., Rodriguez, E., Armstrong, G., Pavone, F., Shrier, A., Bub, G.
Abstract:
Fast, high-resolution volumetric imaging of voltage transients in excitable tissues such as the heart and brain has so far been impossible. We introduce a new imaging modality based on simultaneous illumination and parallel detection of multiple planes to map voltage transients in the intact zebrafish heart at KHz-rates in 3D. The unprecedented resolution of our method enabled the observation of novel dynamics through the zebrafish atrioventricular canal.
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