New blood-based tests for Alzheimer's disease (AD) are advancing and reshaping how this devastating disorder is detected and treated. In this episode, Dr. Christine Cliatt Brown, assistant professor in the division of Cognitive Neurology at the University of Utah, and Dr. Heather Nelson, assistant professor in the department of Pathology at the University of Utah and medical director of Clinical Chemistry and Mass Spectrometry at ARUP Laboratories, discuss how emerging diagnostics are transforming the diagnosis and management of AD. Together, they explore how collaboration across clinical and laboratory disciplines can accelerate diagnostic innovation and support advances in patient care.

Related Information: Plasma-Based Diagnostics for Alzheimer’s Disease: Current State and Clinical Relevance of pTau 217 [aruplab.com/pTau217-2026]

Change is the new constant—especially in clinical laboratories and healthcare organizations. In this episode of LabMind, Danny Diaz, senior director of Clinical Application Services at Memorial Sloan Kettering Cancer Center, shares why resilience is more than a buzzword—it’s an imperative. As he explores his own career journey, Diaz offers practical strategies for building networks, advancing ideas, advocating for yourself, and driving meaningful transformation.

Related Information:

When Uncertainty Knocks: How To Regain Control and Reclaim Confidence https://www.linkedin.com/pulse/when-uncertainty-knocks-how-regain-control-reclaim-confidence-diaz-hn6we/?trackingId=XcqMp8lVT6upzDtJUH%2Fnfg%3D%3D

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a genetic condition that can lead to life-threatening hemolysis in both children and adults. Early and accurate diagnosis is critical, but identifying G6PD deficiency in newborns and young children isn’t always straightforward—most reference intervals are based on adult values, which don’t necessarily apply to pediatric patients. In this interview, Dr. Kelly Doyle, an ARUP medical director of Special Chemistry, Endocrinology, and Mass Spectrometry, shares insights from novel methods to establish pediatric-specific reference intervals. Using an innovative indirect approach and a large dataset of patient results, Dr. Doyle explains how these new standards can improve diagnosis and care for children worldwide. 

Related Information: Webinar: Development of Pediatric G6PD Reference Intervals Through Integration of Indirect Methods and Molecular Data https://arup.utah.edu/education/doyle-g6pd-2025.php

After seven years and almost 100 episodes of LabMind recorded, Dr. Brian Jackson, former medical director at ARUP Laboratories and faculty with the Spencer Fox Eccles School of Medicine at the University of Utah, has moved into a new clinical laboratory leadership position at the University of Maryland—leaving the podcast mic behind for a clinical challenge he always knew he wanted to take in his career. During Dr. Jackson’s final episode, he shares his thoughts on a variety of topics, including the state of U.S. healthcare and the contributions of pathology, while also reflecting on his time hosting this podcast. 

Related Information:

• LabMind - An Interview With Dr. Carl Kjeldsberg (Part I): Founding and the Early Shaping of ARUP https://arup.utah.edu/education/podcasts/labmindEp2.php

• LabMind - An Interview With Dr. Carl Kjeldsberg (Part II): Scaling ARUP into a Mature Company https://arup.utah.edu/education/podcasts/labmindEp3.php

• LabMind - An Interview With Lab Superheroes: Stories of Ingenuity, Creativity, and Grit (Part II) https://arup.utah.edu/education/podcasts/labmindEp50.php

• LabMind - An Interview With Rick Panning: How Laboratories Can Reduce the Total Cost of Care https://arup.utah.edu/education/podcasts/labmindEp36.php

In 2016, Dr. Shaiba Ansari-Ali, a rheumatologist with Northwestern Medicine, experienced a near-fatal stroke that was followed by a misdiagnosed case of sepsis. In this interview, she explains how her positivity and tenacity were key to her successful rehabilitation and recovery, and she illustrates how this experience has made her a better physician despite her physical limitations.

Related Information:

• YouTube Series: “Mansplaining Medicine” (https://www.youtube.com/channel/UCkpqin9U2WgT423DqJo2guQwould) 
• Book: “When the Doctor Has a Stroke: (How I recovered, and you can too)” (https://www.amazon.com/dp/B08LNLCLF9/ref=cm_sw_r_cp_ud_dp_G68R6WEVAJEPMFJFY2CP?skipTwisterOG=1)

As laboratory professionals, we’re often focused on our critical role as part of the healthcare team in delivering results to providers. But, do we ever stop and think about the power laboratory data can have in the hands of the patients themselves? In this interview, Cherise Shockley, a diabetes social media advocate, describes her experience being diagnosed with an under-recognized form of diabetes and shares how her continuous glucose monitor (CGM) and laboratory test results have helped her take control of her disease and her life.

Whenever a new infectious disease enters the scene (or reenters, as in the case of measles), developing precise and accurate diagnostic tests as quickly as possible is critical. In this interview, Dr. Ben Bradley, ARUP medical director of the Institute for Research and Innovation in Infectious Disease Genomic Technologies, High Consequence Pathogen Response, Virology, and Molecular Infectious Diseases, describes various challenges in rapidly setting up and maintaining testing capacity for these kinds of diseases and why we need collaboration between academic, clinical, and public health labs.

Webinar: Emerging Viral Diseases: A 2025 Update for Laboratorians [https://arup.utah.edu/education/bradley-emergingviral-2025.php]; Measles by Real-Time PCR: A Rapid and Reliable Method for Measles Testing [https://www.youtube.com/watch?v=NZdZDPv-oTw]

In this age of algorithms, how do we ensure clinical care is both science based and personalized? In this interview, Dr. Ryan Metcalf, section chief of Transfusion Medicine at ARUP Laboratories and University of Utah Health and associate professor of Pathology at the University of Utah School of Medicine, shares the story behind the new platelet transfusion guideline from the Association for the Advancement of Blood and Biotherapies (AABB). He describes how the authors addressed patient-specific variation and the inherent uncertainty of scientific evidence. 

Related Information: 

• Platelet Transfusion: 2025 AABB and ICTMG International Clinical Practice Guidelines [https://arup.utah.edu/education/metcalf-platelet-2025.php/]
• JAMA® Article: Platelet Transfusion: 2025 AABB and ICTMG International Clinical Practice Guidelines [https://jamanetwork.com/journals/jama/fullarticle/2834703]
• JAMA® Clinical Reviews Podcast: Platelet Transfusion: Best Practice Guidelines [https://edhub.ama-assn.org/jn-learning/audio-player/18977738]

Health equity and personalized medicine share a common goal: tailoring care to the needs of each individual. In this interview, Dr. Octavia Peck Palmer from the University of Pittsburgh Medical Center, immediate past president of ADLM, explains how diversity is foundational to advancing clinical science and improving patient outcomes.

After nearly dying from a mysterious disease during medical school, Dr. David Fajgenbaum dedicated his career to breaking down barriers in biomedical research. Fajgenbaum is now an associate professor of medicine at the University of Pennsylvania and cofounder of Every Cure. In this conversation, we discuss his personal diagnostic journey and the errors and delays he encountered along the way. We also explore why academic medicine needs to go beyond generating disparate pieces of scientific knowledge and instead turn that information into nodes on a network that spans specialty silos to speed the discovery of effective treatments.