Walter Isaacson's biography of Leonardo da Vinci explores the artist's life and work, covering his childhood, apprenticeships, and time spent in Milan and Florence.

The podcast examines da Vinci's diverse talents, including his contributions to painting, engineering, science, and anatomy, highlighting his innovative methods and unfinished projects.

Isaacson's research involved collaboration with leading Leonardo scholars and curators, who provided access to archives and offered expert insights.

The biography analyzes da Vinci's creative process, emphasizing the interplay between observation, imagination, and scientific inquiry.