Parasitic infections have a major impact on the developing world. Their modes of transmission, treatments, and preventions vary widely: Whereas one parasitic infection is nearing eradication without the use of any drug therapy or vaccine, innovative approaches involving immunology, molecular biology and genetics may be required for the elimination of another. Dr. Michael Cappello, professor of pediatrics, microbial pathogenesis, and epidemiology and public health at the Yale School of Medicine, talks with host Dr. Jennifer Shu about what we have learned from these cases, and how these principles can be applied to help reduce other infectious diseases.